Oligo‐astheno‐teratozoospermia in mice lacking <scp>ORP</scp>4, a sterol‐binding protein in the OSBP‐related protein family

Abstract excerpt

Oligo-astheno-teratozoospermia (OAT), a condition that includes low sperm number, low sperm motility and abnormal sperm morphology, is the commonest cause of male infertility. Because genetic analysis is frequently impeded by the infertility phenotype, the genetic basis of many of OAT conditions has been hard to verify. Here, we show that deficiency of ORP4, a sterol-binding protein in the oxysterol-binding...

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