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Article

Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function.

Nature genetics - 1 Mar 2005

Chesler Elissa J, Lu Lu, Shou Siming, Qu Yanhua, Gu Jing, Wang Jintao, Hsu Hui Chen, Mountz John D, Baldwin Nicole E, Langston Michael A, Threadgill David W, Manly Kenneth F, Williams Robert W

Abstract excerpt

Patterns of gene expression in the central nervous system are highly variable and heritable. This genetic variation among normal individuals leads to considerable structural, functional and behavioral differences. We devised a general approach to dissect genetic networks systematically across biological scale, from base pairs to behavior, using a reference population of recombinant inbred strains. We profiled...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15711545
DOI: 10.1038/ng1518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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