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Article

High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.

PLoS neglected tropical diseases - 1 Dec 2011

Chitanga Simbarashe, Marcotty Tanguy, Namangala Boniface, Van den Bossche Peter, Van Den Abbeele Jan, Delespaux Vincent

Abstract excerpt

BACKGROUND: Trypanosomosis caused by Trypanosoma congolense is a major constraint to animal health in sub-Saharan Africa. Unfortunately, the treatment of the disease is impaired by the spread of drug resistance. Resistance to diminazene aceturate (DA) in T. congolense is linked to a mutation modifying the functioning of a P2-type purine-transporter responsible for the uptake of the drug. Our objective was to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22206039
DOI: 10.1371/journal.pntd.0001454
PMCID: PMC3243716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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