Article
High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.
PLoS neglected tropical diseases - 1 Dec 2011
Chitanga Simbarashe, Marcotty Tanguy, Namangala Boniface, Van den Bossche Peter, Van Den Abbeele Jan, Delespaux Vincent
Abstract excerpt
BACKGROUND: Trypanosomosis caused by Trypanosoma congolense is a major constraint to animal health in sub-Saharan Africa. Unfortunately, the treatment of the disease is impaired by the spread of drug resistance. Resistance to diminazene aceturate (DA) in T. congolense is linked to a mutation modifying the functioning of a P2-type purine-transporter responsible for the uptake of the drug. Our objective was to...
Topics
- Africa South of the Sahara
- Alleles
- Animals
- Antiprotozoal Agents
- DNA, Protozoan
- Diminazene
- Disease Models, Animal
- Drug Resistance
- Mice
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Selection, Genetic
- Trypanosoma congolense