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Article

Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense.

Parasitology - 1 Feb 1991

Peregrine A S, Knowles G, Ibitayo A I, Scott J R, Moloo S K, Murphy N B

Abstract excerpt

Nine clones were derived from a drug-resistant Trypanosoma congolense stock (IL 2856) and characterized in mice for their sensitivity to isometamidium chloride and diminazene aceturate. All clones were derived from the stock without drug selection and expressed high levels of resistance to isometamidium chloride (50% curative dose [CD50] values ranging from 1.5 to 5.1 mg/kg) and intermediate to high levels of...

Topics

Animals
Cattle
Diminazene
Drug Resistance
Genetic Variation
Isoenzymes
Mice
Phenanthridines
Phenotype
Trypanocidal Agents
Trypanosoma congolense

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trypanosomiasis, African

Trypanosomiasis, Bovine

Tsetse Flies

Source

Identifiers

PMID: 2038504
DOI: 10.1017/s0031182000060388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2038504-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Variation in resistance to isometamidium chloride and diminazene aceturate by clones derived from a stock of Trypanosoma congolense.PMID 2038504Read ↗

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