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Article

Truncated forms of BNIP3 act as dominant negatives inhibiting hypoxia-induced cell death.

Biochimica et biophysica acta - 1 Mar 2011

Bristow Nicolle, Burton Teralee R, Henson Elizabeth S, Ong-Justiniano Coleen, Brown Michelle, Gibson Spencer B

Abstract excerpt

BNIP3 (Bcl-2/adenovirus E1B Nineteen Kilodalton Interacting Protein) is a pro-cell death member of the Bcl-2 family of proteins. Its expression is induced by the transcription factor Hypoxia Inducible Factor-1 (HIF-1) under conditions of low oxygen (hypoxia) and is found over expressed in hypoxic regions of many tumors. When over expressed, BNIP3 induces cell death through induction of mitochondrial dysfunction...

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Source

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Identifiers

PMID: 21138765
DOI: 10.1016/j.bbadis.2010.11.013
PMCID: PMC3164856

Genes

BNIP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Truncated forms of BNIP3 act as dominant negatives inhibiting hypoxia-induced cell death.PMID 21138765Read ↗

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Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3Semantic proximity Read ↗

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