Article
Chloride transport in nasal ciliated cells of cystic fibrosis heterozygotes.
American journal of respiratory and critical care medicine - 1 May 2005
Sermet-Gaudelus Isabelle, Déchaux Michèle, Vallée Benoît, Fajac Anne, Girodon Emanuelle, Nguyen-Khoa Thao, Marianovski Rémi, Hurbain Ilse, Bresson Jean Louis, Lenoir Gérard, Edelman Aleksander
Abstract excerpt
Studying subjects heterozygous for mutations of the cystic fibrosis (CF) gene may help clarify the impact on disease onset of CF transmembrane conductance regulator protein (CFTR-)-dependent chloride secretion. CFTR-mediated chloride transport was evaluated in 52 heterozygous subjects, 32 healthy control subjects, and 77 patients with CF with class I or II mutations. We measured the change in nasal potential...
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