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Article

ABCB1 haplotype influences the sirolimus dose requirements in Chinese renal transplant recipients.

Biopharmaceutics & drug disposition - 1 Apr 2014

Lee Jun, Huang Hongfeng, Chen Ying, Lu Xiaoyang

Abstract excerpt

Sirolimus, an immunosuppressive drug used to prevent organ rejection after renal transplantation, has a narrow therapeutic index and a large inter-individual variability of pharmacokinetics. The aim of this study was to analyse the dose-normalized trough blood concentrations (C0 /D ratio) of sirolimus in patients with different genotypes and attempt to investigate the possible associations between ABCB1/CYP3A5...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

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Source

Identifiers

PMID: 24285256
DOI: 10.1002/bdd.1881

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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