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Article

Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring.

Human reproduction (Oxford, England) - 1 Jul 2020

Li Jingyu, Cui Linlin, Jiang Xiao, Zhao Han, Zhao Shigang, Shi Yuhua, Wei Daimin, You Li, Ma Jinlong, Chen Zi-Jiang

Abstract excerpt

STUDY QUESTION: Does the inheritance of polycystic ovary syndrome (PCOS) susceptibility single-nucleotide polymorphism affect the phenotype of offspring? SUMMARY ANSWER: Male offspring who inherit PCOS-related genetic variations from PCOS mothers were more susceptible to developing the metabolic abnormality in their later life. WHAT IS KNOWN ALREADY: Genetic factors are considered the major etiology of PCOS....

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PMID: 32619219
DOI: 10.1093/humrep/deaa125

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