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Article

Glycolipids as receptors for Bacillus thuringiensis crystal toxin.

Science (New York, N.Y.) - 11 Feb 2005

Griffitts Joel S, Haslam Stuart M, Yang Tinglu, Garczynski Stephan F, Mulloy Barbara, Morris Howard, Cremer Paul S, Dell Anne, Adang Michael J, Aroian Raffi V

Abstract excerpt

The development of pest resistance threatens the effectiveness of Bacillus thuringiensis (Bt) toxins used in transgenic and organic farming. Here, we demonstrate that (i) the major mechanism for Bt toxin resistance in Caenorhabditis elegans entails a loss of glycolipid carbohydrates; (ii) Bt toxin directly and specifically binds glycolipids; and (iii) this binding is carbohydrate-dependent and relevant for toxin...

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PMID: 15705852
DOI: 10.1126/science.1104444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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