Article
The Caenorhabditis elegans bus-2 mutant reveals a new class of O-glycans affecting bacterial resistance.
The Journal of biological chemistry - 4 Jun 2010
Palaima Elizabeth, Leymarie Nancy, Stroud Dave, Mizanur Rahman M, Hodgkin Jonathan, Gravato-Nobre Maria J, Costello Catherine E, Cipollo John F
Abstract excerpt
Microbacterium nematophilum causes a deleterious infection of the C. elegans hindgut initiated by adhesion to rectal and anal cuticle. C. elegans bus-2 mutants, which are resistant to M. nematophilum and also to the formation of surface biofilms by Yersinia sp., carry genetic lesions in a putative glycosyltransferase containing conserved domains of core-1 beta1,3-galactosyltransferases. bus-2 is predicted to act...
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