Article
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.
Blood - 15 Jun 2005
Morisada Tohru, Oike Yuichi, Yamada Yoshihiro, Urano Takashi, Akao Masaki, Kubota Yoshiaki, Maekawa Hiromitsu, Kimura Yoshishige, Ohmura Masako, Miyamoto Takeshi, Nozawa Shiro, Koh Gou Young, Alitalo Kari, Suda Toshio
Abstract excerpt
Angiopoietin (Ang) signaling plays a role in angiogenesis and remodeling of blood vessels through the receptor tyrosine kinase Tie2, which is expressed on blood vessel endothelial cells (BECs). Recently it has been shown that Ang-2 is crucial for the formation of lymphatic vasculature and that defects in lymphangiogenesis seen in Ang-2 mutant mice are rescued by Ang-1. These findings suggest important roles for...
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