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Article

Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules.

Molecular biology of the cell - 1 Apr 2005

Vedrenne Cécile, Klopfenstein Dieter R, Hauri Hans-Peter

Abstract excerpt

The microtubule-binding 63-kDa cytoskeleton-linking membrane protein (CLIMP-63) is an integral membrane protein that links the endoplasmic reticulum (ER) to microtubules. Here, we tested whether this interaction is regulated by phosphorylation. Metabolic labeling with (32)P showed that CLIMP-63 is a phosphoprotein with increased phosphorylation during mitosis. CLIMP-63 of mitotic cells is unable to bind to...

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Identifiers

PMID: 15703217
DOI: 10.1091/mbc.e04-07-0554
PMCID: PMC1073672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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