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Article

Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promoter.

International journal of molecular medicine - 1 Mar 2005

Hirota Keiko, Aoyama Hisanori, Fukamizu Akiyoshi

Abstract excerpt

HNF-4, a member of the nuclear receptor superfamily, binds to HNF-4 response elements (HRE), consisting of a direct repeat of the hexameric half-sites spaced by 1 nt (direct repeat 1) and activates a number of genes, which play central roles in fatty acids and glucose metabolism. Glucose-6-phosphatase (G6Pase) catalyzes the terminal step in the gluconeogenic and glycogenolytic pathways. A previous study has shown...

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Share to Binding Sites
Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Glucose-6-Phosphatase

Share to Hepatocyte Nuclear Factor 4

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Share to Promoter Regions, Genetic

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PMID: 15702243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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