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Article

Comparison of cAMP-dependent protein kinase substrate specificity in reaction with proteins and synthetic peptides.

Biochimica et biophysica acta - 14 Mar 2005

Loog Mart, Oskolkov Nikita, O'Farrell Fergal, Ek Pia, Järv Jaak

Abstract excerpt

Mutants of L-type pyruvate kinase with modified peptide sequence around the Ser-12 phosphorylation site were prepared and kinetics of their phosphorylation by protein kinase A was studied. The profile of substrate specificity obtained for these proteins was compared with the kinetic data of phosphorylation of short peptide substrates. Alterations made in protein structure caused weaker effects than the...

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Source

Identifiers

PMID: 15698961
DOI: 10.1016/j.bbapap.2004.11.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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