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Article

Peptide backbone conformation affects the substrate preference of protein arginine methyltransferase I.

Biochemistry - 10 Jul 2012

Kölbel Knut, Ihling Christian, Kühn Uwe, Neundorf Ines, Otto Silke, Stichel Jan, Robaa Dina, Beck-Sickinger Annette G, Sinz Andrea, Wahle Elmar

Abstract excerpt

Asymmetric dimethylation of arginine side chains is a common post-translational modification of eukaryotic proteins, which serves mostly to regulate protein-protein interactions. The modification is catalyzed by type I protein arginine methyltransferases, PRMT1 being the predominant member of the...

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Source

Identifiers

PMID: 22697391
DOI: 10.1021/bi300373b

Genes

PRMT1
PABPN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22697391-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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