Article
Characteristics of Saccharomyces cerevisiae gal1 Delta and gal1 Delta hxk2 Delta mutants expressing recombinant proteins from the GAL promoter.
Biotechnology and bioengineering - 20 Mar 2005
Kang Hyun Ah, Kang Woo Kyu, Go Su-Min, Rezaee Abbas, Krishna Sajja Hari, Rhee Sang Ki, Kim Jeong-Yoon
Abstract excerpt
Galactose can be used not only as an inducer of the GAL promoters, but also as a carbon source by Saccharomyces cerevisiae, which makes recombinant fermentation processes that use GAL promoters complicated and expensive. To overcome this problem during the cultivation of the recombinant strain expressing human serum albumin (HSA) from the GAL10 promoter, a gal1 Delta mutant strain was constructed and its...
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