Article
Expression of GAL genes in a mutant strain of Saccharomyces cerevisiae lacking GAL80: quantitative model and experimental verification.
Biotechnology and applied biochemistry - 1 Feb 2004
Verma Malkhey, Bhat Paike Jayadeva, Venkatesh K V
Abstract excerpt
The regulatory network of GAL genes is a model system for the production of foreign proteins. A mathematical model based on steady state was developed for the expression of GAL (galactosidase) genes in a mutant strain of Saccharomyces cerevisiae lacking GAL80. The transcriptional and translational responses of the GAL switch were predicted at various steady-state glucose concentrations. The model predicted...
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