Article
The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation.
The Journal of biological chemistry - 1 Apr 2005
Robitaille Hubert, Proulx Roxanne, Robitaille Karine, Blouin Richard, Germain Lucie
Abstract excerpt
In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined. We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine...
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