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Article

Viscoelastic Gel Formulations Enhance Airway Epithelial Gene Transfer with Viral Vectors

4 Feb 2005

Abstract excerpt

Advances in gene transfer to the conducting airways for the treatment of pulmonary diseases such as cystic fibrosis have identified several vector classes that transduce airway epithelia in vitro and in animal models. One barrier to epithelial gene transfer is the rapid removal of materials from the airway surface via mucociliary clearance. This host defense mechanism limits gene transfer efficiency to airway...

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PMID: 15695737
DOI: 10.1165/rcmb.2004-0410oc

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