Article
Quasispecies heterogeneity of the carboxy-terminal part of the E2 gene including the PePHD and sensitivity of hepatitis C virus 1b isolates to antiviral therapy.
Virology - 10 Oct 2001
Sarrazin C, Bruckner M, Herrmann E, Rüster B, Bruch K, Roth W K, Zeuzem S
Abstract excerpt
Two regions within the HCV genome, hypervariable region 1 (HVR1) within the envelope (E)2 region and the PKR-binding domain (PKRbD) comprising the interferon sensitivity determining region (ISDR) within the nonstructural (NS)5A protein, have been reported to correlate with the outcome of antiviral treatment. Recently, a PKR/eIF2alpha phosphorylation homology domain (PePHD) within the E2 protein of HCV-1 isolates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.