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Article

Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b.

The American journal of gastroenterology - 1 Jun 2003

Saito Takeshi, Ito Takayoshi, Ishiko Hiroaki, Yonaha Mari, Morikawa Kenichi, Miyokawa Akio, Mitamura Keiji

Abstract excerpt

OBJECTIVE: Hepatitis C virus (HCV) E2 protein was recently reported to have a double-stranded RNA-activated protein kinase-eukaryotic initiation factor 2alpha (PKR-eIF2alpha) phosphorylation homology domain (PePHD); PKR is induced by interferon (IFN). PePHD interacts with PKR and inactivates it. PePHD could be a predictor for IFN response, like the interferon sensitivity determination region (ISDR) of HCV NS5A....

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Identifiers

PMID: 12818284
DOI: 10.1111/j.1572-0241.2003.07469.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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