Article
Identification of proliferating dendritic cell precursors in mouse blood.
The Journal of experimental medicine - 1 May 1992
Inaba K, Steinman R M, Pack M W, Aya H, Inaba M, Sudo T, Wolpe S, Schuler G
Abstract excerpt
While it has been known that dendritic cells arise from proliferating precursors in situ, it has been difficult to identify progenitors in culture. We find that aggregates of growing dendritic cells develop in cultures of mouse blood that are supplemented with granulocyte/macrophage colony-stimulating factor (GM-CSF) but not other CSFs. The dendritic cell precursor derives from the Ia-negative and nonadherent...
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