Article
Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus.
The Journal of experimental medicine - 18 Nov 2002
O'Keeffe Meredith, Hochrein Hubertus, Vremec David, Caminschi Irina, Miller Joanna L, Anders E Margot, Wu Li, Lahoud Mireille H, Henri Sandrine, Scott Bernadette, Hertzog Paul, Tatarczuch Lilliana, Shortman Ken
Abstract excerpt
The CD45RA(hi)CD11c(int) plasmacytoid predendritic cells (p-preDCs) of mouse lymphoid organs, when stimulated in culture with CpG or influenza virus, produce large amounts of type I interferons and transform without division into CD8(+)CD205(-) DCs. P-preDCs express CIRE, the murine equivalent of...
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