Article
No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Feb 2005
Deindl Philipp, Peri-Jerkan Silvija, Deichmann Klaus, Niggemann Bodo, Lau Susanne, Sommerfeld Christine, Sengler Claudia, Müller Sebastian, Wahn Ulrich, Nickel Renate, Heinzmann Andrea
Abstract excerpt
Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1....
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