Article
Dendritic cells derived from metastatic cancer patients vaccinated with allogeneic dendritic cell-autologous tumor cell hybrids express more CD86 and induce higher levels of interferon-gamma in mixed lymphocyte reactions.
Cancer immunology, immunotherapy : CII - 1 Jan 2005
Neves Andreia R, Ensina Luis Felipe C, Anselmo Luciene B, Leite Katia R M, Buzaid Antonio C, Câmara-Lopes Luiz H, Barbuto José Alexandre M
Abstract excerpt
Dendritic cells (DCs) are highly effective antigen-presenting cells that, when derived from cancer patients, seem to be functionally deficient. Herein, we show that vaccination with allogeneic DC-autologous tumor cell hybrids affects the phenotype and improves the function of monocyte-derived DCs...
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