Article
Transition mutations in the 23S rRNA of erythromycin-resistant isolates of Mycoplasma pneumoniae.
Antimicrobial agents and chemotherapy - 1 Dec 1995
Lucier T S, Heitzman K, Liu S K, Hu P C
Abstract excerpt
Erythromycin is the drug of choice for treatment of Mycoplasma pneumoniae infections due to its susceptibility to low levels of this antibiotic. After exposure of susceptible strains to erythromycin in vitro and in vivo, mutants resistant to erythromycin and other macrolides were isolated. Their phenotypes have been characterized, but the genetic basis for resistance has never been determined. We isolated two...
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