Article
Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma.
International journal of cancer - 20 Jun 2005
Kondo Satoru, Wakisaka Naohiro, Schell Michael J, Horikawa Toshiyuki, Sheen Tzung-Shiahn, Sato Hiroshi, Furukawa Mitsuru, Pagano Joseph S, Yoshizaki Tomokazu
Abstract excerpt
The Epstein-Barr Virus (EBV) latent membrane protein 1 (LMP1) has a significant role in several malignancies, including nasopharyngeal carcinoma (NPC). LMP1 is the principal oncoprotein, and we have shown that it also induces a set of factors that mediates invasion, angiogenesis and metastasis. Matrix metalloproteinase-1 (MMP1) is also involved in several malignancies. A single guanine insertion polymorphism (2G)...
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