Article
Bax gene G(-248)A promoter polymorphism is associated with increased lifespan of the neutrophils of patients with osteomyelitis.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Apr 2007
Ocaña Marcos G, Valle-Garay Eulalia, Montes A Hugo, Meana Alvaro, Cartón José Antonio, Fierer Joshua, Celada Antonio, Asensi Víctor
Abstract excerpt
BACKGROUND: Patients with osteomyelitis have a decreased rate of spontaneous apoptosis of their peripheral blood neutrophils. The G(-248)A polymorphism in the promoter region of the bax gene is associated with prolonged peripheral blood neutrophil survival in leukemic patients and may play some role in osteomyelitis. METHODS: Bax G(-248)A promoter polymorphism was detected by DNA amplification using polymerase...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
