Article
Genetic diversity in the SIR model of pathogen evolution.
PloS one - 1 Jan 2009
Gordo Isabel, Gomes M Gabriela M, Reis Daniel G, Campos Paulo R A
Abstract excerpt
We introduce a model for assessing the levels and patterns of genetic diversity in pathogen populations, whose epidemiology follows a susceptible-infected-recovered model (SIR). We model the population of pathogens as a metapopulation composed of subpopulations (infected hosts), where pathogens replicate and mutate. Hosts transmit pathogens to uninfected hosts. We show that the level of pathogen variation is well...
Topics
- Biological Evolution
- Genetic Variation
- Influenza A virus
- Models, Biological
- Mutation