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Article

Significance of p53 immunostaining in mesothelial proliferations and correlation with TP53 mutation status.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2022

Naso Julia R, Tessier-Cloutier Basile, Senz Janine, Huntsman David G, Churg Andrew

Abstract excerpt

p53 immunohistochemistry has long been proposed for the separation of benign from malignant mesothelial proliferations, with the older literature suggesting that any degree of positivity supported a diagnosis of mesothelioma. However, using modern immunohistochemistry platforms in other organ systems, notably gynecologic tumors, it has become clear that p53 staining can represent wild-type protein, and only...

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PMID: 34497363
DOI: 10.1038/s41379-021-00920-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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