Article
P53 gene mutation spectrum and the relationship between gene mutation and protein levels in pterygium.
Molecular vision - 18 Jan 2005
Tsai Yi-Yu, Cheng Ya-Wen, Lee Huei, Tsai Fuu-Jen, Tseng Sung-Huei, Chang Kong-Chao
Abstract excerpt
PURPOSE: To investigate the spectrum of p53 gene mutations and the relationship between gene mutation and p53 protein levels in pterygium. METHODS: Pterygial samples were harvested from 51 patients undergoing pterygium surgery. DNA samples for p53 mutation analyses were extracted from epithelial cells and subjected to DNA sequencing for examination of mutations in exons 4, 5, 6, 7, and 8 of the p53 gene. In situ...
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