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Expression of survivin protein in pterygium and relationship with oxidative DNA damage

6 Feb 2008

Abstract excerpt

Ultraviolet radiation is known to cause oxidative DNA damage and is thought to be a major factor implicated in the pathogenesis of pterygium. Among all the photo-oxidative DNA products, the 8-hydroxydeoxyguanosine (8-OHdG) is regarded a sensitive and stable biomarker for evaluating the degree of DNA damage. The protein p53 is a major cell stress regulator that acts to integrate signals from a wide range of...

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PMID: 18266976
DOI: 10.1111/j.1582-4934.2008.00256.x

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