Article
Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes.
Scientific reports - 4 May 2018
Bhat Mohd Younis, Advani Jayshree, Rajagopalan Pavithra, Patel Krishna, Nanjappa Vishalakshi, Solanki Hitendra S, Patil Arun H, Bhat Firdous A, Mathur Premendu P, Nair Bipin, Prasad T S Keshava, Califano Joseph A, Sidransky David, Gowda Harsha, Chatterjee Aditi
Abstract excerpt
Carcinogenic effect of tobacco in oral cancer is through chewing and/or smoking. Significant differences exist in development of oral cancer between tobacco users and non-users. However, molecular alterations induced by different forms of tobacco are yet to be fully elucidated. We developed cellular models of chronic exposure to chewing tobacco and cigarette smoke using immortalized oral keratinocytes. Chronic...
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