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Article

Nicotinic receptor and tobacco-related cancer.

Life sciences - 27 Nov 2012

Russo Patrizia, Cardinale Alessio, Margaritora Stefano, Cesario Alfredo

Abstract excerpt

Currently, tobacco smoking causes approximately 5-6 million deaths per year including more than 35% of all cancer deaths. Nicotine, the addictive constituent of tobacco, and its derived carcinogenic nitrosamines, contribute to cancer promotion and progression through the activation of nicotinic acetylcholine receptors (nAChR). Although the role of nicotine in cancerogenesis is still discussed controversially, it...

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Identifiers

PMID: 22705232
DOI: 10.1016/j.lfs.2012.05.003

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