Article
Inhibition of respiratory syncytial virus fusion by the small molecule VP-14637 via specific interactions with F protein.
Journal of virology - 1 May 2003
Douglas Janet L, Panis Marites L, Ho Edmund, Lin Kuei-Ying, Krawczyk Steve H, Grant Deborah M, Cai Ruby, Swaminathan Swami, Cihlar Tomas
Abstract excerpt
Human respiratory syncytial virus (RSV) is a major cause of respiratory tract infections worldwide. Several novel small-molecule inhibitors of RSV have been identified, but they are still in preclinical or early clinical evaluation. One such inhibitor is a recently discovered triphenol-based molecule, VP-14637 (ViroPharma). Initial experiments suggested that VP-14637 acted early and might be an RSV fusion...
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