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Article

Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay.

Virology - 5 Jul 2003

Morton Craig J, Cameron Rachel, Lawrence Lynne J, Lin Bo, Lowe Melinda, Luttick Angela, Mason Anthony, McKimm-Breschkin Jenny, Parker Michael W, Ryan Jane, Smout Michael, Sullivan Jayne, Tucker Simon P, Young Paul R

Abstract excerpt

Respiratory syncytial virus (RSV) is a ubiquitous human pathogen and the leading cause of lower respiratory tract infections in infants. Infection of cells and subsequent formation of syncytia occur through membrane fusion mediated by the RSV fusion protein (RSV-F). A novel in vitro assay of recombinant RSV-F function has been devised and used to characterize a number of escape mutants for three known inhibitors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12842618
DOI: 10.1016/s0042-6822(03)00115-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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