Breast Cancer Progression and Host Polymorphisms in the Chemokine System: Role of the Macrophage Chemoattractant Protein-1 (MCP-1) −2518 G Allele

Abstract excerpt

Interaction between tumor cells and stroma is essential for tumor growth. Tumor cells stimulate the formation of stromal tissue, which excretes a variety of growth factors, cytokines, and proteases. Tumor-associated macrophages (TAMs) are one of the major components of tumor stromal tissue and are capable of eliciting diverse aspects of tumor growth as either a positive or negative regulator (1). In breast...

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