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Article

Characterization of the Minimal Replicator of Kaposi's Sarcoma-Associated Herpesvirus Latent Origin

29 Jan 2005

Abstract excerpt

The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) binds to two sites within the 801-bp-long terminal repeat (TR) and is the only viral protein required for episomal maintenance. While two or more copies of TR are required for long-term maintenance, a single TR confers LANA-dependent origin activity on plasmid DNA. Deletion mapping revealed a 71-bp-long minimal...

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PMID: 15681465
DOI: 10.1128/jvi.79.4.2637-2642.2005

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Characterization of the Minimal Replicator of Kaposi's Sarcoma-Associated Herpesvirus Latent OriginPMID 15681465Read ↗

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