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Single Molecule Analysis of Replicated DNA Reveals the Usage of Multiple KSHV Genome Regions for Latent Replication

3 Nov 2011

Abstract excerpt

Kaposi's sarcoma associated herpesvirus (KSHV), an etiologic agent of Kaposi's sarcoma, Body Cavity Based Lymphoma and Multicentric Castleman's Disease, establishes lifelong latency in infected cells. The KSHV genome tethers to the host chromosome with the help of a latency associated nuclear antigen (LANA). Additionally, LANA supports replication of the latent origins within the terminal repeats by recruiting...

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PMID: 22072974
DOI: 10.1371/journal.ppat.1002365

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Single Molecule Analysis of Replicated DNA Reveals the Usage of Multiple KSHV Genome Regions for Latent ReplicationPMID 22072974Read ↗

The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Supports Latent DNA Replication in Dividing CellsSemantic proximity Read ↗

KSHV LANA—The Master Regulator of KSHV LatencySemantic proximity Read ↗

KSHV Genome Replication and MaintenanceSemantic proximity Read ↗

Analysis of Viral cis Elements Conferring Kaposi's Sarcoma-Associated Herpesvirus Episome Partitioning and MaintenanceSemantic proximity Read ↗

Timeless-Dependent DNA Replication-Coupled Recombination Promotes Kaposi's Sarcoma-Associated Herpesvirus Episome Maintenance and Terminal Repeat StabilitySemantic proximity Read ↗

Characterization of the Minimal Replicator of Kaposi's Sarcoma-Associated Herpesvirus Latent OriginSemantic proximity Read ↗

Kaposi's Sarcoma-Associated Herpesvirus <i>ori-Lyt</i> -Dependent DNA Replication: DualRole of Replication and Transcription ActivatorSemantic proximity Read ↗

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The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Permits Replication of Terminal Repeat-Containing PlasmidsSemantic proximity Read ↗

Plasticity of DNA Replication Initiation in Epstein-Barr Virus EpisomesSemantic proximity Read ↗

Kaposi’s Sarcoma Herpesvirus Genome PersistenceSemantic proximity Read ↗

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