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Article

Analysis of Viral cis Elements Conferring Kaposi's Sarcoma-Associated Herpesvirus Episome Partitioning and Maintenance

12 Jul 2007

Abstract excerpt

Maintenance of Kaposi's sarcoma-associated herpesvirus (KSHV) episomes in latently infected cells is dependent on the latency-associated nuclear antigen (LANA). LANA binds to the viral terminal repeats (TR), leading to recruitment of cellular origin recognition complex proteins. Additionally, LANA tethers episomes to chromosomes via interactions with histones H2A and H2B (A. J. Barbera et al., Science...

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PMID: 17626102
DOI: 10.1128/jvi.00842-07

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Analysis of Viral cis Elements Conferring Kaposi's Sarcoma-Associated Herpesvirus Episome Partitioning and MaintenancePMID 17626102Read ↗

KSHV Genome Replication and MaintenanceSemantic proximity Read ↗

The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence.Semantic proximity Read ↗

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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Mediates Episome Persistence through <i>cis</i> -Acting Terminal Repeat (TR) Sequence and Specifically Binds TR DNASemantic proximity Read ↗

The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Supports Latent DNA Replication in Dividing CellsSemantic proximity Read ↗

Chromosome Binding Site of Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Is Essential for Persistent Episome Maintenance and Is Functionally Replaced by Histone H1Semantic proximity Read ↗

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Kaposi’s Sarcoma-Associated Herpesvirus LANA Hitches a Ride on the ChromosomeSemantic proximity Read ↗

Characterization of the Minimal Replicator of Kaposi's Sarcoma-Associated Herpesvirus Latent OriginSemantic proximity Read ↗

The Latency-Associated Nuclear Antigen, a Multifunctional Protein Central to Kaposi‘s Sarcoma-Associated Herpesvirus LatencySemantic proximity Read ↗

Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence.Semantic proximity Read ↗

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