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The Latency-Associated Nuclear Antigen, a Multifunctional Protein Central to Kaposi‘s Sarcoma-Associated Herpesvirus Latency

28 Nov 2011

Abstract excerpt

Latency-associated nuclear antigen (LANA) is encoded by the Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) open reading frame 73. LANA is expressed during latent KSHV infection of cells, including tumor cells, such as primary effusion lymphoma, KS and multicentric Castleman's disease. Latently infected cells have multiple extrachromosomal copies of covalently closed circular KSHV genomes (episomes) that are...

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PMID: 22122438
DOI: 10.2217/fmb.11.137

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