Article
Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
BMC medical genetics - 19 Jan 2010
Chiba-Falek Ornit, Nichols Marshall, Suchindran Sunil, Guyton John, Ginsburg Geoffrey S, Barrett-Connor Elizabeth, McCarthy Jeanette J
Abstract excerpt
BACKGROUND: Several studies have noted that genetic variants of SCARB1, a lipoprotein receptor involved in reverse cholesterol transport, are associated with serum lipid levels in a sex-dependent fashion. However, the mechanism underlying this gene by sex interaction has not been explored. METHODS: We utilized both epidemiological and molecular methods to study how estrogen and gene variants interact to influence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.