Article
Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGLU(2/3) receptor agonist LY379268.
Psychopharmacology - 1 Apr 2005
Greco Barbara, Invernizzi Roberto W, Carli Mirjana
Abstract excerpt
RATIONALE: Converging evidence implicates glutamate neurotransmission in attention and inhibitory response control. OBJECTIVE: To investigate how the background genotype contributes to glutamate's effects on attention and response control, we examined how phencyclidine (PCP) affected the performance of a five-choice serial reaction time (5-CSRT) task in two inbred mouse strains, C57BL/6N and DBA/2N. We also...
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