Article
Biparental hydatidiform moles: a maternal effect mutation affecting imprinting in the offspring.
Human reproduction update - 1 Jan 2000
Van den Veyver I B, Al-Hussaini T K
Abstract excerpt
Highly recurrent hydatidiform moles (HMs) studied to date are not androgenetic but have biparental genomic contribution (BiHM). Affected women have an autosomal recessive mutation that causes their pregnancies to develop into HM. Although there is genetic heterogeneity, a major locus maps to chromosome 19q13.42, but a mutated gene has not yet been identified. Molecular studies have shown that maternal imprinting...
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