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Article

BRAF mutation and its inhibitors in sarcoma treatment.

Cancer medicine - 1 Jul 2020

Liu Haotian, Nazmun Nahar, Hassan Shafat, Liu Xinyue, Yang Jilong

Abstract excerpt

The mitogen-activated protein kinase (MAPK) signaling pathway plays a significant role in mediating cellular physiological activities, such as proliferation, differentiation, apoptosis, and senescence. This signaling pathway is composed of several major proto-oncogenes of RAS/RAF/MEK/ERK, among which the BRAF proto-oncogene, as one of the three members of the RAF family, has a higher mutation rate than ARAF and...

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Identifiers

PMID: 32476297
DOI: 10.1002/cam4.3103
PMCID: PMC7367634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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