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Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice.

Experimental & molecular medicine - 31 Dec 2004

Wang Ai-Guo, Moon Hyung-Bae, Lee Young-Ho, Yu Seong-Lan, Kwon Hyun-Jung, Han Ying-Hao, Fang Wan, Lee Tae-Hoon, Jang Kyung-Lib, Kim Sang-Keun, Yu Dae-Yeul, Lee Dong-Seok

Abstract excerpt

Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S1161, are cytopathic to liver, three types of transgenic mice were established. The expression of transgenes was confirmed by HCV specific RT-PCR and Western immunoblotting. The livers of all wild type core and S1161 transgenic lineages remained largely...

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PMID: 15675043
DOI: 10.1038/emm.2004.76

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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