Dose-Dependent Generation of RET/PTC in Human Thyroid Cells after in Vitro Exposure to γ-Radiation: A Model of Carcinogenic Chromosomal Rearrangement Induced by Ionizing Radiation

Abstract excerpt

Ionizing radiation is a well-known risk factor for thyroid cancer in human populations. Chromosomal rearrangements involving the RET gene, known as RET/PTC, are prevalent in thyroid papillary carcinomas from patients with radiation history. We studied the generation of RET/PTC in HTori-3 immortalized human thyroid cells exposed to a range of doses of gamma-radiation and harvested 2, 5-6, and 9 d later. RET/PTC1...

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