Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinctive molecular features of radiation-induced thyroid cancers.

Science advances - 22 Aug 2025

Karyadi Danielle M, Bogdanova Tetiana I, Milder Cato M, Hartley Stephen W, Lee Olivia W, Dean Michael, Drozdovitch Vladimir, Cahoon Elizabeth K, Masiuk Sergii, Chepurny Mykola, Zurnadzhy Liudmyla Yu, Vij Vibha, Kitahara Cari M, Thomas Gerry A, Woloschak Gayle E, Ramsden Dale A, Tronko Mykola D, Chanock Stephen J, Morton Lindsay M

Abstract excerpt

Papillary thyroid carcinoma (PTC) incidence increased after childhood exposure to radioactive fallout from the Chornobyl accident. We investigated PTC genomic profiles to distinguish radiation-induced versus sporadic oncogenic drivers by modeling dose and molecular characteristics by driver category: BRAFV600E (n = 132), RAS mutation (n = 31), fusions generated from two breakpoints and <20 base pairs (bp)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms, Radiation-Induced

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40845117
DOI: 10.1126/sciadv.adw7680
PMCID: PMC12372901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinctive molecular features of radiation-induced thyroid cancers.PMID 40845117Read ↗

Investigation of the Relationship Between Radiation Dose and Gene Mutations and Fusions in Post-Chernobyl Thyroid Cancer.Semantic proximity Read ↗

Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.Semantic proximity Read ↗

Genomic characterization of cervical lymph node metastases in papillary thyroid carcinoma following the Chornobyl accident.Semantic proximity Read ↗

Gene expression signature discriminates sporadic from post-radiotherapy-induced thyroid tumorsSemantic proximity Read ↗

Altered molecular profile in thyroid cancers from patients affected by the Three Mile Island nuclear accident.Semantic proximity Read ↗

<i>RET/PTC</i> Rearrangements Preferentially Occurred in Papillary Thyroid Cancer among Atomic Bomb Survivors Exposed to High Radiation DoseSemantic proximity Read ↗

Mechanisms of Disease: molecular genetics of childhood thyroid cancers.Semantic proximity Read ↗

Oncogenic rearrangements driving ionizing radiation-associated human cancer.Semantic proximity Read ↗

Molecular profiling of papillary thyroid carcinomas in healthcare workers exposed to low dose radiation at the workplace.Semantic proximity Read ↗

Molecular pathogenesis of pediatric thyroid carcinomaSemantic proximity Read ↗

Radiation and Thyroid CancerSemantic proximity Read ↗

Physics Essentials Enable Deeper Understanding in Signaling and Crosstalk of the Carcinogenesis Paradigm "Epistemology of the Origin of Cancer".Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.