Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.

doi:10.1126/science.abg2538

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Article

Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident.

Science (New York, N.Y.) - 14 May 2021

Morton Lindsay M, Karyadi Danielle M, Stewart Chip, Bogdanova Tetiana I, Dawson Eric T, Steinberg Mia K, Dai Jieqiong, Hartley Stephen W, Schonfeld Sara J, Sampson Joshua N, Maruvka Yosef E, Kapoor Vidushi, Ramsden Dale A, Carvajal-Garcia Juan, Perou Charles M, Parker Joel S, Krznaric Marko, Yeager Meredith, Boland Joseph F, Hutchinson Amy, Hicks Belynda D, Dagnall Casey L, Gastier-Foster Julie M, Bowen Jay, Lee Olivia, Machiela Mitchell J, Cahoon Elizabeth K, Brenner Alina V, Mabuchi Kiyohiko, Drozdovitch Vladimir, Masiuk Sergii, Chepurny Mykola, Zurnadzhy Liudmyla Yu, Hatch Maureen, Berrington de Gonzalez Amy, Thomas Gerry A, Tronko Mykola D, Getz Gad, Chanock Stephen J

Abstract excerpt

The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine (131I)-exposed children. We analyzed genomic, transcriptomic, and epigenomic characteristics of 440 PTCs from Ukraine (from 359 individuals with estimated childhood 131I exposure and 81 unexposed children born after 1986). PTCs displayed radiation...

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Identifiers

PMID: 33888599
DOI: 10.1126/science.abg2538
PMCID: PMC9022889

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