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Challenging Dogma in Thyroid Cancer Molecular Genetics—Role of<i>RET/PTC</i>and<i>BRAF</i>in Tumor Initiation

1 Sept 2004

Abstract excerpt

RET/PTC oncogenes are believed to play an important role in the pathogenesis of a significant subset of papillary carcinomas of the thyroid (PTC), in particular those arising after radiation exposure, and in pediatric cancers. Chromosomal rearrangements linking the promoter and N-terminal domains of unrelated gene/s to the C-terminal fragment of RET result in the illegitimate expression of a chimeric form of the...

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PMID: 15356019
DOI: 10.1210/jc.2004-1426

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